Contraindicated in newborns (can cause "gray syndrome" - vomiting, diarrhea, bloating, hypothermia, Jugular Venous Pressure collapse, irregular breathing, skin color pepelnosery; mortality - 40%). Kanamycin is used in the stability of Mycobacterium tuberculosis to streptomycin-Mycin. Used gentamicin with pneumonia, septicemia, meningitis, peritonitis, endocarditis, cholecystitis, acute pyelonephritis, cystitis, prostatitis, purulent infections of the skin, soft tissues, bones, joints, and burn infections caused by sensitive to aminoglycosides microorganisms. Used topically for treatment of infected cuts, scrapes, and burns. Lincomycin is less active and often causes side effects. Polymyxins interacts with phospholipids of the cytoplasmic membrane of microorganisms and Ny violate its permeability. Neomycin is more toxic, is used only locally. Aminoglycosides III generation amikacin, netilmicin similar to the spectrum of action, interaction with gentamicin and tobramycin; differ effective against bacteria resistant to aminoglycosides, I and II smuggler Intramuscularly or intravenously drip. Dysbacteriosis develops Laxative of choice antibiotic suppression of smuggler normal micro-flora of the body. Distinguish 3 generations of aminoglycosides: I generation - streptomycin, kanami-ching, neomycin; II generation - the gentamicin tobramycin; Generation III - amikacin, netilmicin. In 1939 G Domagk (Germany) won the Nobel Prize for his discovery of anti-bacterial effect of prontosil and smuggler . To aminoglycosides II generation smuggler also tobramycin, similar in properties and applications with gentamicin. At the most sensitive microorganisms’ macrolides act tank teriostaticheski. Through chi-toplazmaticheskuyu membrane of bacteria penetrate through oxygen-dependent active transport (and therefore ineffective against anaerobic bacteria). smuggler in relative shenii Mycobacterium tuberculosis. Well into the cells of the body infected by bacteria. With infectious eye diseases (conjunctivitis, keratitis, blepharitis), chloramphenicol is used as eye drops or ointment. In the form of eye ointment is used for blepharitis, conjunctivitis. In contrast to the drugs I generation gentamicin acts on Pseudomonas aeruginosa. Rifampicin is rapidly developing resistance of smuggler Rifampicin appointed interior and intravenously, primarily as a means berkuleznogo protivotu-I series, as well as in the treatment of brucellosis and other diseases caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, osteomyelitis). Organotropic side effects of antibiotics varied. Aminoglycosides are poorly penetrate the bacterial cell wall. Other side effects: stomatitis, glossitis, nausea, vomiting, diarrhea, rash, optic neuritis, encephalopathy. With the destruction of the mass of microbial cells Hyperthermia occurs, which indicates a smuggler efficiency are chosen antibiotic and passes quickly when continuation of chemotherapy. Well pro-arise in the bone tissue. Therefore, at start-Xia Urinary Urea Nitrogen receiving the drug should be discontinued. The drug is not absorbed in the gastrointestinal tract, it can appoint inside with enteritis, as well as to suppress the microbial flora of intestinal ne-ed surgery. Clindamycin is prescribed orally 4 times a day with infectious diseases LORorganov, bone, teeth, joints, of the abdominal cavity caused by susceptible microorganisms.
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